Echoes of a distant past: The cag pathogenicity island of Helicobacter pylori.
نویسندگان
چکیده
This review discusses the multiple roles of the CagA protein encoded by the cag pathogenicity island of Helicobacter pylori and highlights the CagA degradation activities on p53. By subverting the p53 tumor suppressor pathway CagA induces a strong antiapoptotic effect. Helicobacter pylori infection has been always associated with an increased risk of gastric cancer. The pro-oncogenic functions of CagA also target the tumor suppressor ASPP2. In the absence of tumor suppressor genes, cells survive and proliferate at times and in places where their survival and proliferation are inappropriate.
منابع مشابه
Correlation between cag pathogenicity island composition and Helicobacter pylori-associated gastroduodenal disease.
Helicobacter pylori infection is associated with a variety of outcomes ranging from seemingly asymptomatic coexistence to peptic ulcer disease and gastric cancer. The cag pathogenicity island (PAI) contains genes associated with a more aggressive phenotype and has been suggested to be a determinant of severe disease outcome. The cagA gene has served as a marker for the cag PAI. However, the pre...
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ورودعنوان ژورنال:
- Cold Spring Harbor perspectives in medicine
دوره 3 11 شماره
صفحات -
تاریخ انتشار 2013